Are Cisgender Women and Transgender and Nonbinary People Drinking More During the COVID-19 Pandemic? It Depends

PURPOSE This narrative review of research conducted during the first 2 years of the COVID-19 pandemic examines whether alcohol use among cisgender women and transgender and nonbinary people increased during the pandemic. The overarching goal of the review is to inform intervention and prevention efforts to halt the narrowing of gender-related differences in alcohol use. SEARCH METHODS Eight databases (PubMed, APA PsycInfo, CINAHL, Embase, Scopus, Gender Studies Database, GenderWatch, and Web of Science) were searched for peer-reviewed literature, published between March 2020 and July 2022, that reported gender differences or findings specific to women, transgender or nonbinary people, and alcohol use during the pandemic. The search focused on studies conducted in the United States and excluded qualitative research. SEARCH RESULTS A total 4,132 records were identified, including 400 duplicates. Of the remaining 3,732 unique records for consideration in the review, 51 were ultimately included. Overall, most studies found increases in alcohol use as well as gender differences in alcohol use, with cisgender women experiencing the most serious consequences. The findings for transgender and nonbinary people were equivocal due to the dearth of research and because many studies aggregated across gender. DISCUSSION AND CONCLUSIONS Alcohol use by cisgender women seems to have increased during the pandemic; however, sizable limitations need to be considered, particularly the low number of studies on alcohol use during the pandemic that analyzed gender differences. This is of concern as gender differences in alcohol use had been narrowing before the pandemic; and this review suggests the gap has narrowed even further. Cisgender women and transgender and nonbinary people have experienced sizable stressors during the pandemic; thus, understanding the health and health behavior impacts of these stressors is critical to preventing the worsening of problematic alcohol use.

Although historically cisgender women (i.e., women whose sex assigned at birth is consonant with their gender) in the United States have had lower levels of alcohol consumption than cisgender men, recent analyses of historical and cohort data suggest that overall gender differences are narrowing. 1This narrowing is largely due to substantial increases in cisgender women's alcohol use, binge drinking (operationalized as four or more drinks in 1 day for cisgender women; five or more drinks in 1 day for cisgender men) 1,2 and alcohol use disorder (AUD; meets criteria for past 12-month dependence or abuse as established in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders [DSM-V]). 37][8][9] Given that cisgender women may experience more severe alcohol-related problems (e.g., problems in relationships or at work 10 ) and health impacts than do cisgender men, even at lower levels of alcohol use, 11 understanding whether the pandemic has led to an increase in alcohol use among cisgender women is critically important.
Rates and risks for problematic alcohol use vary by sexual identity, [12][13][14] race/ethnicity, 15 and other factors, including socioeconomic status and relationship status. 16These differences may be partially explained by differences in stress levels, including economic stressors and psychological distress 17 and may have been further modified by the coronavirus disease 2019 (COVID-19) pandemic.Research on mental health during the pandemic suggests that cisgender women experienced elevated rates of stress, anxiety, and depression compared to pre-pandemic rates, [18][19][20] at least in the early stages of the pandemic.In contrast, some research has suggested no gender differences in pandemic-related emotional distress. 21,22][28][29] There is evidence of increased problematic alcohol use during previous pandemics; 30 however, the COVID-19 pandemic is unique among recent pandemics in the breadth and duration of its impacts and thus may have more substantial effects on health and well-being, including alcohol use.Cisgender women, compared to cisgender men, may be particularly affected by the pandemic due to higher levels of stressors. 31,32These stressors may be related to negotiating working from home 28 while balancing remote schooling for children, 21,28 higher likelihood of working in frontline and/or caregiver jobs, 28,33 increased risks for intimate partner violence, [34][35][36][37][38] delays in accessing needed health care, 39 isolation, [40][41][42] and potentially higher risks for unintended pregnancies. 31In a prospective study of families, cisgender women, compared to cisgender men, reported higher levels of stressors across four out of five domains.Specifically, cisgender women experienced higher levels of stressors in work/finances (31% increase), home disruptions (64%), social isolation (13%), and health care barriers (94%). 42The burden of pandemic-related stressors, combined with chronic and cumulative stressors disproportionately impacting cisgender women (e.g., sexism and/or violence across the life span 43 ), may result in allostatic overload, which heightens health risks. 44When faced with higher levels of stressors during the pandemic, cisgender women may be at higher risk than cisgender men for alcohol consumption because cisgender women are more likely than cisgender men to use alcohol to cope with negative emotions. 24,45Using alcohol to cope may have potentially disproportionate impacts on those experiencing the highest levels of stressors (e.g., frontline workers, parents). 426][57] TNB people also have experienced disruptions to medical care (including gender-affirming services), which heightens stress. 53,56Coping is a key motivation for alcohol use among TNB populations, 51,58,59 which might suggest increased use of alcohol to cope during a stressful event such as a global pandemic.1][62][63][64] Problematic alcohol use is associated with increased risks for secondary harms that disproportionately affect TNB individuals, such as suicidal ideation, intimate partner violence, sexual violence, and the exacerbation of mental and physical health problems, 62,65,66 highlighting the importance of a deeper understanding of alcohol use among TNB individuals.Additionally, TNB people experience barriers to treatment, 67 including a lack of culturally responsive care options [68][69][70][71][72][73] and discrimination by providers. 68Of note, the umbrella term "TNB" encompasses a diverse range of identities and experiences, but existing research often does not disentangle this diversity, instead aggregating across groups who fall outside of cis-normative gendered expectations and who then are compared with cisgender peers.
Understanding alcohol use among cisgender women and TNB people during the pandemic is particularly important due to risks for severe health outcomes.Not only are COVID-19 patients with AUD more likely to be hospitalized and to have higher all-cause mortality, 74 but alcohol-related mortality spiked with the onset of the COVID-19 pandemic. 75,76Problematic alcohol use also is a major risk factor for COVID-19 infections and mortality. 77Although the connections between COVID-19 and alcohol use have widespread effects, specific alcohol-related health impacts of the pandemic have been particularly harmful for cisgender women, as indicated by a 125% increase in alcohol-associated hepatitis 78 and a stark increase in the proportion of patients screening positive for substance use (including alcohol use) in emergency departments. 79To our knowledge, similar research has not been done among TNB populations.
This review aims to understand the unique experiences of cisgender women and TNB people, as well as among understudied groups of cisgender women such as women of color, sexual minority women (SMW, e.g., lesbian, bisexual, queer women), and older women to describe subgroup impacts of the COVID-19 pandemic on alcohol use.A recent scoping review of substance use during the pandemic noted the importance of examining substance use (including alcohol) during the pandemic among cisgender women and TNB populations. 80Thus, this review aims to evaluate the extant literature testing whether cisgender women drank at similar or higher levels than cisgender men during the pandemic.The review further explores alcohol use among TNB populations during the pandemic, with a focus on gender differences in rates of alcohol use (e.g., binge drinking, alcohol dependence, quantity/frequency of drinking) in research conducted during the pandemic (since March 2020) in the United States.

Search Methods Employed
This narrative review of alcohol use during the pandemic was conducted to document whether alcohol use had increased among women-a population already experiencing inclines in alcohol use before the pandemic-and among TNB people in order to inform needed prevention and interventions, as well as to inform policy.The review process included seven steps: [81][82][83]  All records found via the database searches were exported to an EndNote library (version X9).Duplicates were identified and removed in EndNote, and the remaining library was imported into the Covidence review software to facilitate identifying relevant articles for the narrative review.Articles were eligible for inclusion in this review if they met the following criteria hierarchically: (1) were published in peer-reviewed journals between March 2020 and July 2022; (2) were written in English; (3) used human participants in the United States (to reduce variability in responses to the pandemic); (4) included measurement of alcohol use (broadly defined); (5) collected data during the COVID-19 pandemic; and (6) included analyses of gender differences in rates of alcohol use or focused solely on cisgender women or TNB people and alcohol use during the pandemic.Articles were excluded if they were review papers or qualitative studies, if they did not conduct any gender differences analyses (unless the study focused on women or TNB samples only), and if alcohol was not an outcome.

Data Extraction
After conducting a title and abstract review of all articles, the authors reviewed the full text of the remaining papers to determine final inclusion.Differences were discussed amongst three authors until agreement was reached.The full texts of the 400 articles were assessed for relevance to the review's aims.When an article was excluded during the full review, authors documented the reason for its exclusion.(See Figure 1 for the search strategies for both questions combined.)Three authors critically reviewed and synthesized data from the 51 included articles.

Results of the Literature Search
The literature search identified a total of 4,132 records.There were 400 duplicates, leaving 3,732 unique records for consideration in the review; of these, 51 articles ultimately were included.

Results of the Reviewed Studies
Appendices 1 and 2 (located after the references) list the 51 reviewed articles and include all data from the abstraction protocol.Consistent with the goals of a narrative review, potential methodological limitations of the research are highlighted to help the reader better evaluate the validity and generalizability of the findings.The results are broken into four sections: (1) prevalence; (2) specific populations and demographic differences (age, race/ethnicity) or life experiences (pregnancy, intimate relationships, frontline work); (3) linkages between alcohol and mental health, stress, or coping; and (4) TNB individuals and SMW.
Table 1 includes descriptive data of the studies reviewed.Of those, 24% included nationally representative samples, 36% included pre-pandemic data (as opposed to retrospective reporting or only having within-pandemic data), 51% had data collection that ended early in the pandemic (March-May 2020), and 16% had data collection that ended in 2021.Slightly more than one-quarter (26%) used the Alcohol Use Disorders Identification Test (AUDIT) or AUDIT-Consumption (AUDIT-C), with several studies using just one or two items from the AUDIT.In addition, 6% used another validated measure, and 29% examined quantity and frequency only.Of those studies that looked at gender differences (as opposed to having a sample of cisgender women only), 73% found gender differences in alcohol use.
Of the 51 studies that met inclusion criteria, 20 studies tested for trends over time in alcohol use, including the pandemic period.Table 2 summarizes the results of those 20 studies, including the number of studies that found increases, decreases, or no change in alcohol use.Overall, 12 of the 20 studies documented increases in alcohol use during the pandemic period.More studies documented increases among cisgender women than among cisgender men (8 and 6 out of 13, respectively), and the only study with sufficient data to test for trends among TNB individuals found increases in alcohol consumption.
The following sections present the results in more detail, organized by prevalence data; specific subpopulations; stress, coping, and mental health; and alcohol use among SMW and TNB people.Not all studies had mutually exclusive samples; thus, studies may be mentioned in more than one section.

Prevalence
Eighteen studies were primarily aimed at describing prevalence of alcohol use among adults during the pandemic and included analyses of gender differences.These studies were divided into two groups: cross-sectional studies (including repeated crosssectional studies) of adults and longitudinal/prospective studies of adults.

Cross-sectional general population adult studies
Nine cross-sectional studies, 79,[84][85][86][87][88][89][90][91] all conducted during the early pandemic, met inclusion criteria.All used convenience samples, with two samples recruited from social media.In three studies that asked participants to compare retrospectively their pre-pandemic AUD symptoms to current symptoms, [85][86][87] all found increased reports of AUD symptoms among cisgender women during the early pandemic compared with retrospective reports of pre-pandemic symptoms.In one study, cisgender men also reported increases; 85 in another, they did not; 86 and in the third study cisgender women reported increased drinking more often than did cisgender men. 87A fourth study found no gender differences in self-defined "drinking behaviors" during the early pandemic. 88Across these studies, the cross-sectional designincluding retrospective reporting of pre-pandemic drinking behaviors and AUD symptoms as well as use of convenience samples based on volunteers from social media-limit the conclusions that can be drawn from these studies.
Three general population adult studies used repeated cross-sectional assessments (with different samples at each time point) before and during the pandemic to compare rates across time. 79,84,89Using nationally representative samples, Kerr et al. 89 documented that daily drinking and alcohol volume were higher among cisgender women interviewed during the pandemic through 2021 compared to those interviewed pre-pandemic.AUD prevalence across the continuum from mild to severe was also higher during the pandemic.Sensitivity analyses indicated that results were robust to the timing of interviews and thus unlikely to be affected by pandemic-related social distancing policies.Electronic health record data of more than 100,000 patients visiting emergency departments showed higher alcohol admissions and evaluations for cisgender women during the pandemic compared with rates before the use, cisgender men had higher levels of alcohol use (i.e., average number of drinks per day) than cisgender women at baseline (April-June 2019).However, alcohol use in cisgender men declined over time (last wave of data collection was in March 2021), whereas it stayed the same over time in cisgender women. 100In an additional nationally representative study with data from 2019 through the early months of the pandemic, days consuming alcohol and heavy drinking days (defined as five or more drinks within "a couple of hours" for cisgender men and four or more drinks for cisgender women) increased among cisgender women. 99Of note, however, no longitudinal studies of the general adult population included data beyond January 2021, and no studies published in 2022 met inclusion criteria for this review.Given that surveys were completed by telephone both before and during the pandemic, it is unlikely that study methodology was substantially impacted by COVID-era research policies, although an impact on willingness to participate in research (either more or less willing) cannot be excluded and could be a limitation.However, taken together, the available research indicates that days consuming alcohol and heavy drinking days on average increased among cisgender women in the general population during the early and middle periods of the pandemic, but that for both variables, their consumption levels largely remained lower than, and did not change at the same rate as, those of cisgender men.pandemic. 79In contrast, expenditure data, as an indirect measure of alcohol consumption, indicated lower household alcohol expenses during the pandemic, compared with pre-pandemic levels, for both cisgender men and cisgender women.However, expenditures may not correlate precisely with volume sales-for example, if purchases moved from on-premise to off-premise. 84epeated cross-sections of data provide sufficient rigor for assessing changes in time trends, and all three studies included pre-pandemic time points, a notable strength.Given that two of the three studies found that increases in relatively serious alcohol-related harm (e.g., AUD, alcohol-related emergency department admissions) are concentrated among cisgender women, these data indicate an emerging concern.

Longitudinal general population adult studies
][94][95][96][97][98][99][100] Three of these were based on a single data source, the Understanding America Study (UAS), 92,95,97 a nationally representative panel study conducted monthly, with published data through mid-2020.All three studies from UAS demonstrated increases in alcohol consumption during the pandemic using repeated-measures longitudinal analyses, including increases in drinking days and near-daily drinking among cisgender women.However, these increases generally were less than those seen in cisgender men and remained below drinking levels among cisgender men. 92,95,97In a representative online sample of adults, among those who reported any alcohol during the pandemic; and binge drinking (i.e., five or more drinks in a row). 110,111A sixth study reported higher odds of drinking (any drinking on previous day) among cisgender men compared with cisgender women but noted no changes during the pandemic period. 112he remaining studies of college students and young adults generally found either faster declines in drinking among cisgender men, 106 or faster increases, 109 compared with cisgender women.A study comparing alcohol consumption during college spring semester across 3 years (2018, 2019, and 2020) found that whereas alcohol consumption (operationalized as number of drinking days and drinks per day) generally increased during spring semesters pre-pandemic, alcohol consumption either did not increase or declined in 2020 depending on the measure; 107 no gender differences were found.The most robust studies (e.g., Jaffe et al. 2021 107 ) indicate that college drinking largely declined in the early pandemic period, which is expected as students moved off campus, but there is little evidence for gender differences in these declines.
In sum, research among college students and young adults is mixed.Some studies found higher levels of alcohol use among cisgender men and some among cisgender women; however, overall, there were no increases in alcohol use among cisgender young women during the pandemic.Only one study identified for this review focused on older adults. 113In this study, which included a nationwide sample of older adults, cisgender women accounted for 59% of those who reported drinking more than usual during the pandemic.

Demographic differences by race/ethnicity
Only two studies focused on race/ethnicity and alcohol consumption during the pandemic. 114,115Among a sample of American Indian cisgender women followed prospectively through October 2021, approximately a quarter reported self-perceived increased consumption and half reported binge drinking (i.e., four or more "standard" drinks per day) during the pandemic. 114Among Black, indigenous, and other people of color (BIPOC) undergraduate students prospectively followed from before the pandemic through spring 2020, declines in drinking frequency were reported, but cisgender women, compared with cisgender men, were less likely to show declines. 115Overall, the sparse research is mixed on alcohol use among BIPOC cisgender women during the pandemic, suggesting that more research is needed.

Couple relationships and pregnancy
7][118] The study of cisgender women and

Specific Populations and Demographic Differences
Several studies focused on unique subpopulations of cisgender women and alcohol use during the pandemic.The following sections discuss unique impacts on different age groups, different racial/ethnic populations, cisgender women in couple relationships, those who are pregnant or who are parents, and those who are frontline workers.

Adolescents, young adults, and older adults
Five cross-sectional studies met inclusion criteria; four [101][102][103][104] were among young adult college undergraduates, and one was a nationally representative survey of high school students. 105No study had pre-pandemic data, and data collection spanned from early in the pandemic through early 2021.In the only nationally representative study of high school students meeting inclusion criteria, 105 cisgender women students had higher rates of current alcohol consumption (defined as at least one drink in the past 30 days) than cisgender men students but did not report that they thought they drank more due to the pandemic.A cross-sectional survey of undergraduate college students conducted in fall 2020, with retrospectively reported pre-pandemic drinking, indicated increased consumption during the pandemic among all groups. 103oreover, consumption and increases in consumption were greater among cisgender men compared with cisgender women and TNB individuals.Sexual minority groups generally reported higher levels of alcohol consumption and greater increases compared with pre-pandemic levels in both the high school and college samples; however, none of the studies examined interactions between sexual identity and gender.When coupled with the use of convenience samples, the cross-sectional designs and retrospective reporting limit inference from studies among college students.
Two studies included repeated cross-sectional samples of college students, 103,104 one of which included pre-pandemic data collection. 103AUD prevalence was higher during the pandemic compared with pre-pandemic, with increases concentrated among cisgender women compared with cisgender men.For example, 49.7% of cisgender women met criteria for AUD during the pandemic, compared with 34.4% before the pandemic.
Seven studies [106][107][108][109][110][111][112] included longitudinal data among young adults (two of the seven from the same data source 109,110 ).All had pre-pandemic data points, a major strength of the evidence base.However, the span of pandemic data collection was limited to the early pandemic through late 2020.Two had nationally representative data (most used convenience samples). 108,112ost of these studies only reported data through spring 2020, which provides a limited assessment of pandemic-era changes in alcohol consumption, and findings regarding gender differences were mixed.0][121][122][123][124][125][126] However, only five of these studies examined whether the associations between alcohol and stress or mental health differed by gender, 94,100,120,121,124 three of which included pre-pandemic data. 100,120,124Two studies demonstrated mixed findings about drinking to cope early in the pandemic among cisgender women. 100,120One study found significant associations between COVID-related stressors and drinking to cope, with stronger associations for cisgender men than cisgender women. 120In the other study, stronger coping motives for drinking were associated with higher drinking levels at baseline for cisgender women, and loneliness and coping were related to changes in drinking levels over time. 100nalyses using data from a quasi-experimental study of a nationally representative sample determined that cisgender women interviewed during the pandemic (compared to cisgender women interviewed pre-pandemic) were nearly 1.5 times more likely to report that drinking helped them forget their worries. 124mong cisgender women, single women (compared to married women) were more likely, and Black women (compared to white women) were less likely to report drinking to forget their worries.Cisgender women with moderate to severe symptoms of depression (compared to no depressive symptoms; adjusted odds ratio: 2.45) and mild symptoms of anxiety (compared to no anxiety symptoms; adjusted odds ratio: 1.62) were significantly more likely to say that drinking helped them cope with their worries. 124There were no differences among cisgender men and no differences in comparisons between cisgender women and cisgender men.Depression and anxiety were associated with heightened risks for alcohol use 121 and drinking to cope 124 among cisgender women during the pandemic.

TNB Individuals and SMW TNB populations
8][129][130][131] These studies included five cross-sectional and two prospective analyses, primarily began data collection in early pandemic, and all had trans-specific sample sizes of 200 or less.Within the literature that examined the drinking behaviors and trajectories of TNB people following the onset of COVID-19, the referent group to which TNB people were compared varied across studies.In some studies, the comparison was between TNB people and cisgender (or specifically cisgender and heterosexual) peers. 128,130,131In other studies, TNB people were aggregated and compared against cisgender women. 115,127,129One study included solely TNB people and evaluated their current behaviors against their retrospectively reported pre-pandemic behaviors. 101hese comparisons provide differing information on TNB people's drinking during the COVID-19 pandemic.Comparisons their men partners during the pandemic detected no gender differences in drinking levels; however, cisgender men reported more alcohol problems than did cisgender women.Cisgender women's general stress and financial stress had no impacts on their partners' drinking (drinks per week); however, cisgender men's stress was associated with an increase in their partners' drinking and a 22% increase in their own and their partners' highintensity drinking (defined as 10 or more drinks per day for men and eight or more drinks per day for women). 118here are mixed findings among pregnant cisgender women in reports of changes in alcohol use during the pandemic.Among a convenience sample of pregnant cisgender women, 11% reported perceived increases in their own and 28% in their partners' alcohol use since the pandemic's beginning.In contrast to these findings, none of the pregnant cisgender women in a study of centers for high-risk pregnancies reported self-perceived increases in alcohol use since the start of the pandemic. 116Notably, in the same study, 10% of postpartum cisgender women reported increased alcohol use. 116ogether these findings suggest that in couple relationships during the pandemic, cisgender men's stress levels and drinking may be associated with increased alcohol use and high intensity drinking among cisgender women.Findings among pregnant and postpartum women are mixed but suggest pregnancy and postpartum periods may heighten risk for some cisgender women.However, research was lacking on pregnant and postpartum TNB people during the pandemic, and further work should examine the impact of pregnancy more inclusively.

Frontline workers
Due to high levels of stress and risks for exposure to COVID-19 for health care and other frontline workers during the pandemic, research on health and health behaviors is important for understanding the broad impacts on this population.Yet, only two studies on frontline workers met inclusion criteria. 85,119mong health care workers in New Orleans, there were no significant gender differences in AUDIT-C scores.However, cisgender men's rates of high-risk drinking (defined as a score of 4 or greater) stayed the same over time (45% at both time points), whereas cisgender women's rates of high-risk drinking were higher during the pandemic compared to pre-pandemic (48% vs. 45%, respectively). 85In another study among health care workers at 25 hospitals, adjusted analyses found that cisgender women were no more likely than cisgender men to have symptoms consistent with probable AUD despite significantly higher likelihood of probable post-traumatic stress disorder (PTSD). 119

Coping, Stress, and Mental Health
The literature search yielded 10 studies that analyzed gender differences in alcohol use and also tested associations consequences and motivation to drink to cope.In the analysis of the entire sample, participants indicated drinking on 26% of days as compared to using cannabis on 32% of days.On drinking days, participants consumed an average of almost three drinks per day and endorsed coping motives on 57% of drinking days. 127Overall, findings indicate higher incidence of increased alcohol use during the pandemic among sexual minority women compared to cisgender heterosexual women and sexual minority men; these increases were associated with higher risks for poor mental health.Notably, none of the studies reviewed included pre-pandemic data, and only one study was prospective. 127Two studies including sexual identity difference analyses (e.g., bisexual compared to lesbian cisgender women) within sexual minority women found few to no differences. 127,128hree studies included only young adults; 127,128,132 only one study included participants from a wider age range (anyone older than age 18 was eligible). 133

Discussion
This review of the extant literature suggests that alcohol consumption, and especially reports of alcohol-related problems such as AUD symptoms, increased among adults in the United States during the pandemic.Although not all studies were entirely concordant, many increases in the most serious consequences of alcohol consumption seemed to be concentrated in cisgender women.That said, most studies, especially those representative of the U.S. population, indicate that alcohol consumption and alcohol-related harms remain higher among cisgender men.With respect to different subpopulations, data among young adults suggest that alcohol consumption in this age group declined in the early pandemic, with little evidence for gender differences in the decline.][136][137][138] In the limited research that examined alcohol use among TNB populations, evidence suggests minimal differences in drinking frequency and other drinking outcomes (e.g., rates of increased drinking) between TNB and cisgender populations, at least when the comparison was between TNB people and either cisgender women or cisgender/heterosexual individuals. 115,127,129,131hen compared with sexual minority college students, TNB college students had a lower likelihood of problem drinking (as determined using AUDIT) and a higher likelihood of selfreporting substantial changes in drinking during the pandemic. 130NB college students exhibited increases in mean number of between TNB people and cisgender women, which were assessed at a variety of pandemic time points, typically found no significant differences between these groups in terms of alcohol use frequency (e.g., number of drinks consumed in a given day), alcohol use changes (e.g., self-reported drinking frequency before and during the pandemic), and likelihood of drinking to cope.115,127,129 For the literature comparing TNB populations to cisgender or cisgender/heterosexual peers more generally, TNB people and cisgender/heterosexual peers had comparable rates of increased drinking during the pandemic (TNB: 10.5%; cisgender/heterosexual: 13%) and were equally likely to exhibit problem drinking (based on PROMIS scores).131 Compared to cisgender men and SMW peers, TNB respondents reported a lower likelihood of problem drinking (using AUDIT), 130 even though they reported higher psychological distress during the early pandemic.128 However, based on self-report, TNB respondents were more likely to report substantial increases in drinking during the pandemic.Notably, these results are drawn solely from college students.130 Other research on college students that drew from a more general sample addressed these substantial changes in drinking due to the pandemic, finding that mean number of drinks in the past 30 days among "non-cisgender" people, using the phrasing of that study, rose from 9.2 pre-pandemic (February 2020) to 16.8 during the pandemic (October 2020).However, these levels were lower than among either cisgender men or women peers.101 Extant research on TNB people's drinking during the pandemic yielded conflicting results, with the most common result being null findings of differences between TNB people and cisgender peers across a number of drinking outcomes (though this varied based on the specific comparison being drawn).This small pool of research also lacked examinations of other TNB-specific factors that may influence drinking during the pandemic, such as transphobic experiences or sustained access to trans-related and trans-affirming health care as a preventive measure against psychological distress.

Sexual minority women
Four studies included findings specific to cisgender SMW. 127,128,132,133More SMW than any other group reported self-perceived increases in alcohol use since the start of the pandemic (39% vs. 33% of sexual minority men and 24.5% of cisgender heterosexual women). 133Two of the studies used the same sample but reported on different time points in recruitment (earlier in recruitment 132 and after all participants had been recruited 127 ).Among participants who were recruited earlier in the study/pandemic, most reported increased anxiety and depression since before the pandemic (more than 90%), but fewer reported increases in drinking (40% to 55% reported increases in drinking quantity, frequency, or both). 132Increases in anxiety and depression were associated with more alcohol increased, 22,26,27,152 which may put more people, particularly cisgender women, including SMW and TNB people, at higher risk of problematic alcohol use.

Limitations of the Review
One key limitation of this review is the focus on alcohol; different forms of substance use can co-occur, potentially amplifying associated health risks. 80Research is limited on co-occurring substance use among cisgender women and TNB populations during the COVID-19 pandemic.Future research should address co-occurring substance use among cisgender women, sexual minority populations, and TNB populations to thoroughly examine its impact.
This review focuses solely on peer-reviewed publications, which may have led to a limitation of the research reviewed as only 16% of studies included time points in 2021 and none extended into 2022.Perhaps little research was conducted in 2021 that looked at the continued impacts of the pandemic on alcohol use; alternatively, findings may not yet be available in the peer-reviewed literature.Timing is important as different stages of the pandemic may have influenced population alcohol use heterogeneously; moreover, different geographic locations had discrete experiences of the pandemic.For example, the first case of COVID-19 in the United States was documented in January 2020 in Washington State, and cases were largely concentrated on the west coast until March 2020.Stay-at-home orders began in early to mid-March in some areas (e.g., Puerto Rico, California, New Jersey) whereas some states did not issue them until April (e.g., Iowa, South Carolina, Missouri). 153Many cities and states temporarily suspended bar and restaurant operations in the initial stages of the pandemic, which may have made alcohol less accessible; however, countervailing alcohol policies in many states that eased restrictions on take-out and home delivery of alcohol may have counteracted restrictions on on-premise consumption. 154,155Similarly, stressors associated with the initial stages of the pandemic could have contributed to higher rates of alcohol use compared with later stages of the pandemic.However, the extent to which stress eased as the pandemic continued remains understudied.Moreover, evidence suggests that boredom during the pandemic also may have been associated with increased alcohol use. 156,157rticles rarely mentioned when data collection occurred, much less with enough specificity to ensure it occurred during the pandemic, which made it difficult to screen out articles that collected data prior to 2020.To facilitate screening and identification of articles only looking at alcohol use during the pandemic, the authors made the decision to include "COVID" as part of the search strategy to capture relevant literature in the time available for the review and minimize the potential for not finding relevant studies.It would be beneficial to update this review in the future once more research has been published; drinks in the past 30 days over the pandemic, but baseline levels were lower than in cisgender men and women peers. 101However, this body of research would benefit from clearer, more nuanced analyses that disentangle the rich diversity of TNB identities and stratify cisgender people by gender and sexual identity.Further research also is warranted on the specific experiences of TNB college students, as this population exhibited unique patterns.Additionally, research on pandemic drinking trajectories among TNB populations would benefit from a stronger emphasis on trans-specific experiences and stressors that may influence alcohol use; this research should be encouraged as an avenue of further inquiry.
Research among LGBTQ people during the pandemic broadly seems to suggest few to no differences compared with cisgender heterosexual populations. 104,139Notably, however, alcohol use seems to have increased since before the pandemic among sexual minority women, 133 and these increases are associated with worsened mental health. 127,1281][142][143][144][145] More research is needed to understand the stressors and mechanisms underlying the higher rates of alcohol use among sexual minority women during the pandemic.
Efforts to combat elevated drinking must account for the complex reasons why people drink.Cisgender women were more likely to drink to help forget worries after (compared to before) the onset of the pandemic, 124 and economic stressorssuch as pay decreases, difficulty paying bills, or losing one's job during the pandemic-have all been linked to increased drinking among cisgender women. 146Using alcohol as a coping mechanism impacted both TNB populations and cisgender women, as drinking to cope during the pandemic occurred at similar levels for both groups 127 and was higher for TNB people and cisgender women than for cisgender heterosexual men. 147isgender women also experienced greater levels of unpaid labor (e.g., taking care of family members) during the pandemic, which may have increased stress levels. 31,1485]150 Pandemic-related stressors may be particularly impactful for cisgender women's drinking, 151 but the potential impacts on TNB people's drinking is less clear.Further research is needed to fully articulate any stressors and coping practices unique to TNB populations during the pandemic, such as potential shifts in proximal stress (e.g., anticipated stigma, concealment, or internalized transphobia), which has been linked to problematic alcohol use and drinking to cope. 58hether the associations between mental health concerns and alcohol use were heightened during the pandemic is underresearched; however, rates of depression and anxiety have measures were perhaps necessary given the lack of prepandemic data collection in many studies but may have resulted in substantial measurement error.Further, definitions of alcohol use (e.g., problems, binge drinking) varied, making comparisons across studies challenging.Finally, given the heterogeneity of measures employed and domains of alcohol use examined, the current literature is limited in its ability to allow for any kinds of conclusions about differential rates of drinking versus alcohol problems.
Very few studies focused on BIPOC populations, which is particularly troubling given the sizable racial/ethnic disparities in COVID-19 infections and deaths 159 and the compounding impacts of sociopolitical events, racism (including anti-Asian hate/attacks), xenophobia, and economic concerns on wellbeing. 160,161The review also found few studies that included comparisons between cisgender and TNB populations, and those that did lacked sample sizes to conduct subgroup comparisons among TNB people (e.g., transgender men versus transgender women), despite discrete risks. 64TNB populations are underrepresented in gender differences research; thus, more research on alcohol use among TNB people during the pandemic is needed to better understand rates of alcohol use and unique risk factors.Similarly, despite identified high risks among SMW, studies examining LGBTQ subgroups often had extremely small sample sizes for these groups, limiting the capacity for studies to identify significant differences.Few studies reported the intersections between gender and sexual identity (e.g., comparing bisexual men and bisexual women), thus limiting our understanding of gender differences.
No studies looked at gender differences in parenting and how that might be associated with potentially higher risk for alcohol use.Little research examined alcohol use among couples, despite ample research demonstrating partners' impacts on each other's drinking 162,163 and clear linkages between intimate partner violence and alcohol, 164,165 as well as the increased risks for intimate partner violence during the pandemic. 35,36,166ne of the clearest limitations of the literature was the overall lack of research examining gender differences, which may be additionally related to the challenges of doing research during the height of the pandemic.The shift to working from home and the demands of social distancing made in-person research challenging, if not impossible, which had downstream implications for new research recruitment and data collection.Moreover, the pandemic had unequal impacts on the productivity of women and researchers from marginalized groups, [167][168][169][170][171] which may have had disproportionate impacts on rates of research focused on cisgender women, BIPOC women, and TNB populations during the pandemic.however, this review gives a preliminary look at the available evidence.
This review excluded studies conducted outside of the United States, given the great variance in how different countries responded to the pandemic.Indeed, a recent systematic review suggests sizable variance in alcohol use during the pandemic depending on the country. 158This U.S.-centric review limited understanding of alcohol use by cisgender women and TNB people during the pandemic on a broader scale.Anecdotally, it was noted that many papers that examined gender differences or focused on cisgender women's alcohol use were conducted outside of the United States.Future reviews should broaden the search to be inclusive of these important studies.Finally, the review excluded qualitative research, as the focus was on rates of alcohol use rather than on more nuanced findings related to reasons for alcohol use or experiences during the pandemic.

Limitations of the Literature
Among the reviewed literature, the most robust designs were longitudinal, multi-cohort approaches and included prepandemic data (e.g., Jaffe et al. 107 ).Pre-pandemic longitudinal data allow for assessment of pandemic-related deviations from existing patterns.For example, college students typically increase alcohol consumption during the spring semester; therefore, increases in alcohol use in spring 2020 during the pandemic period are not atypical and, in fact, might have been lower than expected. 107Another limitation is that most studies did not test for gender-by-time interactions; as a result, there are limited data on whether or not gender differences existed in changes over time.Examination of gender differences was further complicated by a frequent lack of clarity as to whether studies were reporting on sex or gender, or simply reporting on "women" without specifying how many of these women were cisgender or TNB.Generally, if studies did not mention TNB people in their study population, it is likely that TNB status was either not measured or considered, or that TNB people were actively excluded.Thus, in this review, studies that did not discuss gender outside of cisgender women and men, or that only used the terms "women" and "men," were presumed to be not inclusive of TNB people.
Another limitation related to research design is measurement of alcohol use, changes in alcohol use, and other alcohol-related outcomes.Although many studies used validated measures of alcohol problems or commonly used measures of quantity and frequency, others relied on more subjective assessments.For example, 28% of the reviewed studies measured change in alcohol use by asking participants for their perceptions of change since the pandemic's start, and 8% of studies asked participants to retrospectively report drinking levels pre-pandemic and current drinking.Retrospective subjective comparisons of alcohol use before and during the pandemic with unvalidated delivery).Some of those pandemic-related changes are becoming permanent in some states. 194Revisiting alcohol regulation, including increasing price, as a public health approach could have considerable public health benefits.

Summary of Conclusions
The gender gap in alcohol use is narrowing between cisgender men and women-and seems to have gotten even narrower during the pandemic.Additionally, cisgender women and TNB people are less likely to seek treatment, and there may be unique health risks related to COVID-19 and alcohol use at least for cisgender women.Thus, research, prevention, and intervention efforts are needed to address this public health issue.Halting this worrisome trend in alcohol use by cisgender womenacross sexual identities-requires a public health approach that considers the unique needs and concerns of cisgender women.More research also is needed to understand alcohol use by TNB individuals during the pandemic and how to best build resilience and support for this underserved population.Ultimately, this paper is about both sex and gender, capturing the drinkingrelated experiences of cisgender women (for whom these align) and TNB populations (for whom they do not), as well as various subpopulations that may face unique risks (such as pregnant people).Thus, findings suggest that research on alcohol use and other mental health concerns needs to take both sex and gender (including gender-diverse individuals beyond just comparisons between cisgender men and women) into account to understand not only differences in rates and changes over time but also differences in predictors and outcomes.

Implications
The findings of this review point to a continued need for alcoholreduction interventions.A discussion of the complexities of cisgender women's and TNB people's treatment utilization is beyond the scope of this review.However, there are unique pandemic-related considerations that may be worth attention.Although the extent to which pandemic-related increases in alcohol consumption will persist over the long term remains unknown, available research from disasters indicates that AUDs exacerbated by disaster exposures can persist over time for some individuals; 172 thus, considering alcohol treatment and service capacity and pre-pandemic disparities is warranted.Interventions to reduce alcohol consumption and treat symptoms of AUDs have well-documented efficacy.However, before the pandemic, cisgender women 5 and TNB individuals 62,67,173 already had diminished rates of service utilization that may have been exacerbated in the pandemic setting.Digitally delivered services may increase access across populations, 174,175 yet cisgender women, including SMW, and TNB people have more complex comorbidities that may require higher levels of care. 5,67,176,1775][186][187] Thus, an urgent research priority stemming from these findings is to evaluate accessibility and acceptance of service modalities.
There have been calls not to treat mental health concerns or problematic health behaviors as individual-level issues, particularly during a ubiquitous stressful and public health crisis such as a global pandemic. 188,189Instead, interventions should take a public health approach by modifying social and contextual factors to build resiliency. 160,190,191People have multiple motives for drinking, such as cravings 192 or enhancing social situations. 112et, the unique impacts of pandemic-related stressors warrant enhancing access to resources, both emotional and economic, that may, in turn, help decrease stress-and coping-related motivations to drink.Efforts aimed at reducing distress and lowering risks for problematic alcohol use thus need to focus on ensuring consistent population-level access to resources such as social support, childcare and elder care, sick leave, affordable and accessible health care (including mental health care), affordable and permanent housing, education, living wages, and access to accurate health information.Whether these alone would be sufficient during a pandemic to reduce barriers to accessing help and uniquely support cisgender women and TNB people is unknown.
Further, alcohol policies to reduce access are effective in reducing harm. 193Alcohol policies generally became more permissive during the pandemic (e.g., "to-go" drinks, home  Quantity and frequency Self-report of current drinking at more than one time point Yes Pre-pandemic (retrospectively reported), cisgender men drank more than cisgender women who drank more than TNB participants; during pandemic, consumption increased across groups, but remained cisgender men > cisgender women > TNB; cisgender men and TNB participants had greatest percent change during pandemic.Quantity and frequency, current binge drinking Self-perceived changes in alcohol use Yes Cisgender women higher than cisgender men for current and binge drinking; no differences in perceived changes since pandemic.Sexual minority students reported higher current alcohol use, binge drinking, and drinking during the pandemic than did heterosexual students.
Graupensperger 106 Quantity/frequency; Drinks per occasion Self-report of current drinking at more than one time point Yes At baseline, cisgender women lower drinking than cisgender men; drinking declined at follow-up; declines were greater for cisgender men than cisgender women (significant interaction).

Appendix 1 .
Description of Studies Included in This Review (N = 51): Sample Sizes, Recruitment Methods, Study Design, and Timing of Start and Stop of Data Collection* and Repeated Cross-Sectional Studies of General Population Adults 1 Chandran 79

104 "
higher AUD symptoms than cisgender women.No pre-pandemic data and no time by gender interaction tested.During the last two months, how often have you engaged in alcohol use?" Retrospective report of current drinking in past vs drinking now No Gender differences tested but not significant.Alcohol use worsened between spring and fall 2020.5 Brener 105

8 Miech 108 "
drinking days, greater drinks per day (both across years and within 2020); college students did not increase drinking in spring 2020 as was typical in previous years; no gender by time interaction reported.Think back over the last 2 weeks.How many times have you had five or more drinks in a row?" Pre-and post/during pandemic data No Study found that past 2-week binge declined from spring to summer 2020 overall; no overall gender differences; did not test time by gender interaction.9 Romm 109 Past 30-day quantity and frequency Self-report of current drinking at more than one time point Yes Baseline drinking was lower for cisgender men than cisgender women; increases in alcohol use during pandemic greater for cisgender men than cisgender women Appendix 2. Description of Studies Included in This Review (N = 51): Measurement of Alcohol Use and Changes in Alcohol Use and Brief Findings* (Continued) The first strategy comprised a combination of search strings related to alcohol use, COVID-19, and women.The second strategy combined search strings for alcohol use, COVID-19, SMW, and TNB populations.No filters were applied to the search results.

Table 2 . Summary of Results for Changes in Drinking After Onset of COVID-19 Pandemic
*Percentages within each group may not total 100% due to rounding.Note: COVID-19, coronavirus 2019.

Description of Studies Included in This Review (N = 51): Sample Sizes, Recruitment Methods, Study Design, and Timing of Start and Stop of Data Collection* (Continued)
Articles are listed in the order in which they appear in the manuscript.Some studies are listed in more than one section of the table.†Time periods for start and stop of research studies: Pre-pandemic (Before March 2020); Early pandemic (March-May 2020); Late 2020 (June-December 2020); Early 2021 (January-May 2021); Late 2021 (June-December 2021).Note: AFAB, assigned female at birth; AUD, alcohol use disorder; COVID-19, coronavirus disease 2019; EHR, electronic health record; EMA, ecological momentary assessment; HIV+, human immunodeficiency virus-positive; LGBT, lesbian, gay, bisexual, transgender; LGBTQ+, lesbian, gay, bisexual, transgender, and queer or questioning; MACS, Multicenter AIDS Cohort Study; NAS, National Alcohol Survey; RAND ALP, RAND American Life Panel; RCT, randomized controlled trial; TNB, transgender and nonbinary; WIHS, Women's Interagency HIV Study.Appendix *

1. Description of Studies Included in This Review (N = 51): Sample Sizes, Recruitment Methods, Study Design, and Timing of Start and Stop of Data Collection* (Continued)
YesSignificant gender differences, but no pairwise differences reported.Cisgender men had double the rates of reporting 13 or more drinks in a week than did cisgender women; other drinking levels did not differ.cisgender women drank less than cisgender men; in change models, increased drinking during the month was no different between cisgender men and women, but cisgender women less likely to decrease drinking.more likely to be in the 'any binge drinking' trajectory group.Significant gender by time interaction; both cisgender men and women exhibited significant binge drinking decreases at time three compared to time one; decrease larger in cisgender men.1% of cisgender women and 32.9% of cisgender men reported hazardous drinking at baseline.Did not test gender by time interaction.Yes Analyses were stratified by gender.Cisgender men's alcohol use started out higher than cisgender women but declined whereas cisgender women's stayed static.By time 3, drinking levels were about the same.Both cisgender men and cisgender women had increased alcohol problems over time.Coping and social reasons for drinking and loneliness had distinct associations with alcohol use, alcohol problems, and change over time and these varied by gender.